DREAMers Awareness Project

Our purpose is to work from the very core of the Latino community. We will go into our local high schools: Central High School and Salem-­‐Keizer School District. Sometimes, for students who are first generation and have no prior knowledge of what it takes to go to college, the process can be intimidating and discouraging. We will place all the helpful tools we’ve received from meetings, mentors, clubs, etc. in one insightful presentation which we can follow up with one to one mentoring. We want to be that source of insight that we wished we could’ve had back when we were younger; it only takes one person to propel a student into higher education.https://digitalcommons.wou.edu/maurice/1012/thumbnail.jp

Community-Based Health and Exposure Study around Urban Oil Developments in South Los Angeles.

Oilfield-adjacent communities often report symptoms such as headaches and/or asthma. Yet, little data exists on health experiences and exposures in urban environments with oil and gas development. In partnership with Promotoras de Salud (community health workers), we gathered household surveys nearby two oil production sites in Los Angeles. We tested the capacity of low-cost sensors for localized exposure estimates. Bilingual surveys of 205 randomly sampled residences were collected within two 1500 ft. buffer areas (West Adams and University Park) surrounding oil development sites. We used a one-sample proportion test, comparing overall rates from the California Health Interview Survey (CHIS) of Service Planning Area 6 (SPA6) and Los Angeles County for variables of interest such as asthma. Field calibrated low-cost sensors recorded methane emissions. Physician diagnosed asthma rates were reported to be higher within both buffers than in SPA6 or LA County. Asthma prevalence in West Adams but not University Park was significantly higher than in Los Angeles County. Respondents with diagnosed asthma reported rates of emergency room visits in the previous 12 months similar to SPA6. 45% of respondents were unaware of oil development; 63% of residents would not know how to contact local regulatory authorities. Residents often seek information about their health and site-related activities. Low-cost sensors may be useful in highlighting differences between sites or recording larger emission events and can provide localized data alongside resident-reported symptoms. Regulatory officials should help clarify information to the community on methods for reporting health symptoms. Our community-based participatory research (CBPR) partnership supports efforts to answer community questions as residents seek a safety buffer between sensitive land uses and active oil development

Influencia de la familia en el rendimiento académico escolar de los estudiantes de primero básico A de la escuela José Artigas

Tesis (Profesor de Educación General Básica)Esta investigación tiene como principal objetivo conocer y analizar la influencia de la familia en el rendimiento académico escolar de los estudiantes de primero básico A de la Escuela José Artigas. Estos indicadores fueron recogidos y comparados principalmente con aplicación de instrumentos y observación obtenida durante la ejecución de la práctica profesional y desempeño laboral que comprenden entre el mes de marzo y diciembre del presente año. El análisis y trayecto investigativo, se sustenta en una población estudiantil de 723 alumnos aplicando una muestra determinada de 39 niños que conforman un curso. Para ello se utilizan instrumentos de evaluación que nos permiten medir de alguna forma que tan comprometidos está la familia y entorno de un estudiante en su desarrollo académico a través de un enfoque cuantitativo y un diseño descriptivo. Para la presente investigación nos enfocamos en diversos autores relacionados con el área educativa, también mediante los estudios realizados por la UNESCO y el MINEDUC (Ministerio de Educación), entre otros, que nos ayudan como referencia en nuestro proceso. En los capítulos a continuación se detallan los procesos empleados, la organización de éstos y las conclusiones obtenidas de los diversos análisis realizados. De esta manera podremos comprender y ayudar en el proceso formativo académico de nuestros estudiantes

Plantão psicológico na clínica-escola de psicologia da Universidade Federal da Grande Dourados

O plantão psicológico constitui-se como uma forma contemporânea de atendimento baseado em referencial teórico clínico, adaptado para suprir demandas de pessoas em busca de atendimento psicológico de urgência. O objetivo deste trabalho consiste em apresentar um relato de experiência de um projeto de extensão aliado a uma proposta de estágio específico do Curso de Psicologia da Universidade Federal da Grande Dourados (UFGD). O plantão psicológico foi implantado, na clínica-escola de psicologia, configurando-se como a porta de entrada dos serviços da Psicologia, visando um pronto atendimento qualificado, acolhendo a população que fosse encaminhada ou que buscasse o serviço espontaneamente. Participaram do projeto 53 acadêmicos do último ano do Curso de Psicologia, no período de 2014 a 2017. O serviço se estrutura da seguinte forma: a) entrevistas iniciais para acolher a demanda; b) acompanhamento com realização do psicodiagnóstico interventivo ou orientação e escuta; e, c) encerramento com finalização do processo havendo possibilidade de alta ou encaminhamento para psicoterapia familiar ou individual, realizada na própria clínica-escola, ou para serviços externos. Entende-se, de modo geral que o Plantão Psicológico se mostrou fundamental para a adesão dos pacientes aos encaminhamentos, bem como, para a formação dos estagiários, que puderam vivenciar uma modalidade alternativa de atendimento em Psicologia

Plan estratégico de la empresa Mobile Inc.

Este trabajo tiene como finalidad presentar un plan estratégico 2020-2024 para la empresa Mobile Inc., el cual consiste en desarrollar estrategias que le permitan alcanzar el objetivo corporativo planteado que es “lograr una eficiente estructura de costos para maximizar el retorno sobre la inversión de la empresa”. Para asegurar el logro de este objetivo, se han desarrollado planes de marketing y ventas, operaciones, recursos humanos (RR. HH.), responsabilidad social y finanzas, los cuales cubren la estrategia propuesta y diferenciada en cada territorio. Entre los objetivos planteados, tenemos incrementar las ventas en 34% al final de este periodo y alcanzar una cuota de mercado global de 1,5%. Además, invertir en investigación y desarrollo (I + D) para seguir desarrollando nuevas tecnologías de manera interna e incrementar gradualmente el margen de utilidad neta sobre los ingresos por ventas hasta alcanzar 15% al cierre del 2024

CTCF cis-Regulates Trinucleotide Repeat Instability in an Epigenetic Manner: A Novel Basis for Mutational Hot Spot Determination

At least 25 inherited disorders in humans result from microsatellite repeat expansion. Dramatic variation in repeat instability occurs at different disease loci and between different tissues; however, cis-elements and trans-factors regulating the instability process remain undefined. Genomic fragments from the human spinocerebellar ataxia type 7 (SCA7) locus, containing a highly unstable CAG tract, were previously introduced into mice to localize cis-acting “instability elements,” and revealed that genomic context is required for repeat instability. The critical instability-inducing region contained binding sites for CTCF—a regulatory factor implicated in genomic imprinting, chromatin remodeling, and DNA conformation change. To evaluate the role of CTCF in repeat instability, we derived transgenic mice carrying SCA7 genomic fragments with CTCF binding-site mutations. We found that CTCF binding-site mutation promotes triplet repeat instability both in the germ line and in somatic tissues, and that CpG methylation of CTCF binding sites can further destabilize triplet repeat expansions. As CTCF binding sites are associated with a number of highly unstable repeat loci, our findings suggest a novel basis for demarcation and regulation of mutational hot spots and implicate CTCF in the modulation of genetic repeat instability

Uncovering a Macrophage Transcriptional Program by Integrating Evidence from Motif Scanning and Expression Dynamics

Macrophages are versatile immune cells that can detect a variety of pathogen-associated molecular patterns through their Toll-like receptors (TLRs). In response to microbial challenge, the TLR-stimulated macrophage undergoes an activation program controlled by a dynamically inducible transcriptional regulatory network. Mapping a complex mammalian transcriptional network poses significant challenges and requires the integration of multiple experimental data types. In this work, we inferred a transcriptional network underlying TLR-stimulated murine macrophage activation. Microarray-based expression profiling and transcription factor binding site motif scanning were used to infer a network of associations between transcription factor genes and clusters of co-expressed target genes. The time-lagged correlation was used to analyze temporal expression data in order to identify potential causal influences in the network. A novel statistical test was developed to assess the significance of the time-lagged correlation. Several associations in the resulting inferred network were validated using targeted ChIP-on-chip experiments. The network incorporates known regulators and gives insight into the transcriptional control of macrophage activation. Our analysis identified a novel regulator (TGIF1) that may have a role in macrophage activation

FUTURE-AI: International consensus guideline for trustworthy and deployable artificial intelligence in healthcare

Despite major advances in artificial intelligence (AI) for medicine and healthcare, the deployment and adoption of AI technologies remain limited in real-world clinical practice. In recent years, concerns have been raised about the technical, clinical, ethical and legal risks associated with medical AI. To increase real world adoption, it is essential that medical AI tools are trusted and accepted by patients, clinicians, health organisations and authorities. This work describes the FUTURE-AI guideline as the first international consensus framework for guiding the development and deployment of trustworthy AI tools in healthcare. The FUTURE-AI consortium was founded in 2021 and currently comprises 118 inter-disciplinary experts from 51 countries representing all continents, including AI scientists, clinicians, ethicists, and social scientists. Over a two-year period, the consortium defined guiding principles and best practices for trustworthy AI through an iterative process comprising an in-depth literature review, a modified Delphi survey, and online consensus meetings. The FUTURE-AI framework was established based on 6 guiding principles for trustworthy AI in healthcare, i.e. Fairness, Universality, Traceability, Usability, Robustness and Explainability. Through consensus, a set of 28 best practices were defined, addressing technical, clinical, legal and socio-ethical dimensions. The recommendations cover the entire lifecycle of medical AI, from design, development and validation to regulation, deployment, and monitoring. FUTURE-AI is a risk-informed, assumption-free guideline which provides a structured approach for constructing medical AI tools that will be trusted, deployed and adopted in real-world practice. Researchers are encouraged to take the recommendations into account in proof-of-concept stages to facilitate future translation towards clinical practice of medical AI

A genome-wide association search for type 2 diabetes genes in African Americans.

African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P<0.0071), were directionally consistent in the Replication cohort and were associated with T2DM in subjects without nephropathy (P<0.05). Meta-analysis in all cases and controls revealed a single SNP reaching genome-wide significance (P<2.5×10(-8)). SNP rs7560163 (P = 7.0×10(-9), OR (95% CI) = 0.75 (0.67-0.84)) is located intergenically between RND3 and RBM43. Four additional loci (rs7542900, rs4659485, rs2722769 and rs7107217) were associated with T2DM (P<0.05) and reached more nominal levels of significance (P<2.5×10(-5)) in the overall analysis and may represent novel loci that contribute to T2DM. We have identified novel T2DM-susceptibility variants in the African-American population. Notably, T2DM risk was associated with the major allele and implies an interesting genetic architecture in this population. These results suggest that multiple loci underlie T2DM susceptibility in the African-American population and that these loci are distinct from those identified in other ethnic populations